Av juan pablo duarte. this one is the newest and the biggest in santiago with many stores like ifix from apple inc. and many clothing stores.
Las colinas. this one is recognized by a huge supermarket called jumbo and for having lots of accesories stores.
There are 3 big shopping Centres in Santiago.
Av juan pablo duarte. where you can find brand stores like oscar d la renta, bossini, addidas, levi's, benetton, nautica and others.
But if you like more cheap things you should go to the city centre specially to Calle del Sol and all streets around.
If you are willing to buy more sophisticated stuff you could visit: Charo, La Rosé, Kakey, Eternia....